Summer 2022  
image showing the polyomics logo and a stylised molecular network
 

Welcome

Glasgow Polyomics is delighted to be moving to the Joseph Black Building later in the year!

We hope that the main campus location will extend the reach of technologies offered by Polyomics, improve access to our resources and expertise, and strengthen our support for research in UofG and externally. The date of our move is not definite, but we will keep staff informed. We will do all we can to minimise any disruption to our services!

*** We welcome enquires via our website on potential collaborations, grants and projects. ***

Follow us on Twitter @polyomics to stay informed of our activities, research involvement and upcoming courses!

Next Generation Sequencing

We were delighted to discuss advances in single cell sequencing and spatial transcriptomics with the CEO of 10X Genomics during his visit to Glasgow. Polyomics will also be hosting Oxford Nanopore in September, where they will be presenting their new GridION technology.

Since the arrival of NextSeq2000, the sequencing output increased by 100% due to a combination of higher throughput and lower prices!

Proteomics

Michaela Kunzova visited GP Proteomics from the lab of Alena Zikova in the Czech Republic for 3 months, to collect data on the role of protein oxidation in the trypanosome life cycle. Sponsored by EMBO, this visit supported training and knowledge exchange, and has allowed Polyomics to develop new redox sensitive multiplex proteomics workflows that will be of interest to other facility users

Metabolomics and Lipidomics

The metabolomics team have been testing the analysis of dried blood spots (DBS). This method of sample collection is much quicker and easier than drawing blood, reduces sample preparation complexity and offers new opportunities within the clinic and for field sample collection. The results so far have been very encouraging! If this sounds of interest to you please get in touch to discuss how this may fit into your research protocols.

Data Analysis

We are delighted to share that our work on improving acquisition methods for tandem mass spectrometry has been published in Analytical Chemistry. Using real-time peak detection and intelligent fragmentation scheduling, we were able to increase the coverage of fragmented metabolites by up to 2x from conventional Top-N DDA approach. This means potentially doubling the number of metabolites that could be identified in an untargeted experiment. If you are interested in learning more or applying this to your own data, please contact us.

Training

We hope those who attended the Galaxy Workshop in May enjoyed it and will now be more familiar with the Galaxy Platform. We were thrilled to welcome staff from the Lighthouse Lab in Glasgow to the Introduction to Omics, and have had some excellent feedback, thank you!

We will be running a variety of courses after the summer break:

 

College of Medical, Veterinary and Life Sciences