Mani joined Glasgow Polyomics in 2012 as a bioinformatician, and he is involved in analysing next-generation sequencing and microarray-based genomics and transcriptomics data, and mass spectrometry-based proteomics and metabolomics data. Although now working in bioinformatics research, he was originally trained as a veterinarian and obtained a professional veterinary degree (BVSc & AH), from Nagpur Veterinary College, India, and worked as a veterinary clinician and a ‘Special Officer’ for the Government of Tamil Nadu, India for 9 years. His immense desire to keep abreast in the cutting edge of drug discovery brought him to the UK to do an MSc in Applied Bioinformatics at Cranfield University. He then joined the Pfizer-Translational Medicine Research Collaboration (TMRC) as a bioinformatics analyst before moving to the ‘Data Analysis Group’ led by Professor Geoff Barton at the University of Dundee. He is currently enrolled for a part-time PhD with the University of Glasgow and he is expecting to complete his PhD in 2016
Integrating large-scale biological datasets
Mani is interested in the development of methods and algorithms to integrate large scale 'omics' datasets (genomics, transcriptomics, proteomics and metabolomics) to analyse them at different dimensions, and to identify biologically meaningful insights from the emergent properties. He is also interested in integration of clinical data with omics data using eTRIKS/tranSMART clinical data platform and Apache Hadoop-related analytical tools.
Biomarker discovery and Translational medicine
Mani is a named researcher in a UK multi-centre study (ORBIT) to identify prognostic biomarkers using RNA-Seq and LC-MS-based metabolomics to tailor biological therapies in Rheumatoid Arthritis. He is also involved in another cohort study that integrates DNA-seq, RNA-Seq and miRNA-Seq to identify prognostic biomarkers to direct biologic therapy in patients with Rheumatoid Arthritis. Previously, he contributed to colorectal cancer diagnostic biomarker discovery, renal cell carcinoma (RCC) diagnostic biomarker discovery, chronic obstructive pulmonary disease (COPD) target discovery and canine lymphoma translational projects.