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Mani MUDALIAR - Bioinformatician

Photograph of Polyomics staff member

Mani joined Glasgow Polyomics in 2012 as a bioinformatician, and he is involved in analysing next-generation sequencing and microarray-based genomics and transcriptomics data, and mass spectrometry-based proteomics and metabolomics data. Although now working in bioinformatics research, he was originally trained as a veterinarian and obtained a professional veterinary degree (BVSc & AH), from Nagpur Veterinary College, India, and worked as a veterinary clinician and a ‘Special Officer’ for the Government of Tamil Nadu, India for 9 years. His immense desire to keep abreast in the cutting edge of drug discovery brought him to the UK to do an MSc in Applied Bioinformatics at Cranfield University. He then joined the Pfizer-Translational Medicine Research Collaboration (TMRC) as a bioinformatics analyst before moving to the ‘Data Analysis Group’ led by Professor Geoff Barton at the University of Dundee. He is currently enrolled for a part-time PhD with the University of Glasgow and he is expecting to complete his PhD in 2016

Integrating large-scale biological datasets

Mani is interested in the development of methods and algorithms to integrate large scale 'omics' datasets (genomics, transcriptomics, proteomics and metabolomics) to analyse them at different dimensions, and to identify biologically meaningful insights from the emergent properties. He is also interested in integration of clinical data with omics data using eTRIKS/tranSMART clinical data platform and Apache Hadoop-related analytical tools.

Biomarker discovery and Translational medicine

Mani is a named researcher in a UK multi-centre study (ORBIT) to identify prognostic biomarkers using RNA-Seq and LC-MS-based metabolomics to tailor biological therapies in Rheumatoid Arthritis. He is also involved in another cohort study that integrates DNA-seq, RNA-Seq and miRNA-Seq to identify prognostic biomarkers to direct biologic therapy in patients with Rheumatoid Arthritis. Previously, he contributed to colorectal cancer diagnostic biomarker discovery, renal cell carcinoma (RCC) diagnostic biomarker discovery, chronic obstructive pulmonary disease (COPD) target discovery and canine lymphoma translational projects.

Selected Publications

  • Speakman, C.M., Domke, C.E.T., Wongpaiboonwattana, W., et al. (2014). Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naïve to primed cell transition. Stem Cells. 32(10):2605-15.
  • Atrih, A., Mudaliar, M.A.V., Zakikhani, P., et al. (2014). Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling. Br J Cancer. 110, 1622-1633.
  • Mudaliar, M.A.V., Haggart, D.R., Miele, G., et al. (2013). Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL). PLoS ONE 8(9): e72591.
  • Mackenzie, K.F., Clark, K., Naqvi, S., et. al. (2013). PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol, 190, 565-77.
  • Lee, C.M., Mudaliar, M.A.V., Haggart, D.R., et. al. (2012). Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology. PLoS ONE 7(12): e48238.
  • For more information and publications please visit my ReseachGate profile or Google Scholar page.

Grants Awarded

  • Assessing the impact of foot-and-mouth vaccination programs in India. BBSRC. 2013 – 2017.
  • International collaboration to explore the milk microbiome in dairy cattle. Wellcome Trust ISSF Catalyst Grant. 2013 – 2014.
  • Urine microbiome of livestock and wildlife as a source of zoonotic bacteria in Tanzania. Wellcome Trust ISSF Catalyst Grant. 2013 – 2014.